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A new version of multistateutils has been released onto CRAN containing a few new features. I’ll give a quick overview of them here, but have a look at the vignette for more examples. msprep2 The first is a replacement for the mstate::msprep function that converts data into the long transition-specific format required for fitting multi-state models. msprep requires the input data to be a in a wide format, where each row corresponds to an individual and each possible state has a column for entry time and a status indicator.


Having become interested in football again due to the World Cup, I was thinking about Predictaball and how I never wrapped up the season with a brief review. It’s been a big season for Predictaball, with the move to an Elo-based system, as well as the launch of a website. However, is the new match forecasting method any good? Model accuracy Fortunately, to help answer this question, a very generous Twitter user by the name of Alex B has been collecting weekly Premiership match predictions from around 30 models and tracked their progress.


A month ago I mentioned that I’d been using a discrete event simulation for estimating transition probabilities from parametric multi-state models. I’ve now turned this code into a general package containing resources for multi-state modelling, called multistateutils (I know, I’m very imaginative) which may be of interest to other people working with multi-state models in R. The current release is available on CRAN, while the development is still on GitHub.


I’m very happy to announce the first ‘official’ release of version 1.0.0 of rprev, the R package for estimating disease prevalence by simulation. This is useful for epidemiologists who have registry data and want to know disease prevalence from time periods longer than is covered by the registry. I first released it almost exactly two years ago but had always intended to update it with the features in this release.


I’ve just returned from the 2018 Survival Analysis for Junior Researchers conference in Leiden, fresh with inspiration and wishing I was a PhD student again to have the luxury of time and independence to research all the ideas in my head. As with previous years it was extremely well organised with a variety of interesting talks, I particularly enjoyed the sessions on Causal Inference and Dynamic Prediction and hope to incorporate some of what I’ve learnt into my work.


Recent publications

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This talk discussed on an application of multi-state modelling to predict treatment pathways of a disease with heterogeneous disease management options, often involving multiple lines of active treatment.
Survival Analysis for Junior Researchers 2018, 2018.

Despite having notable advantages over established machine learning methods for time series analysis, reservoir computing methods, such as echo state networks (ESNs), have yet to be widely used for practical data mining applications. In this paper, we address this deficit with a case study that demonstrates how ESNs can be trained to predict disease labels when stimulated with movement data. Since there has been relatively little prior research into using ESNs for classification, we also consider a number of different approaches for realising input–output mappings. Our results show that ESNs can carry out effective classification and are competitive with existing approaches that have significantly longer training times, in addition to performing similarly with models employing conventional feature extraction strategies that require expert domain knowledge. This suggests that ESNs may prove beneficial in situations where predictive models must be trained rapidly and without the benefit of domain knowledge, for example on high-dimensional data produced by wearable medical technologies. This application area is emphasized with a case study of Parkinson’s disease patients who have been recorded by wearable sensors while performing basic movement tasks.
Artificial Intelligence in Medicine, 2018.

This work presented an interactive web application for building multi-state models of disease pathways. The app is flexible, allowing for both parametric and semi-parametric models, with transition-specific distributions. The presentation won the award for Best Presentation.
Survival Analysis for Junior Researchers 2017, 2017.

A survey of possible ways to evaluate survival models that are intended for prognostic, rather than inferential aims. The work was demonstrated on a clinically motivated data set of Follicular Lymphoma. This presentation won the Best in Session Award.
Survival Analysis for Junior Researchers 2016, 2016.

Ensembles are groups of classifiers which cooperate in order to reach a decision. Conventionally, the members of an ensemble are trained sequentially, and typically independently, and are not brought together until the final stages of ensemble generation. In this paper, we discuss the potential benefits of training classifiers together, so that they learn to interact at an early stage of their development. As a potential mechanism for achieving this, we consider the biological concept of mutualism, whereby cooperation emerges over the course of biological evolution. We also discuss potential mechanisms for implementing this approach within an evolutionary algorithm context
Information and Processing in Cells and Tissues, 2015.


A Multi-State Modelling web app

A web app built in Shiny to visualise Multi-State Models


A machine learning sports prediction bot


An R package for estimating disease prevalence from registry data